South Park is a first-person shooter. The game's single-player mode places the player in control of one of the four main characters of South Park (Cartman, Kyle, Stan or Kenny). The player must defeat a variety of enemies using the various weapons found throughout each stage in order to reach the exit point at the end.
In addition to completing levels, the player must also prevent large enemies in the stage (dubbed 'Tanks') from reaching the exit before they do. If they fail to do so, they will be forced to defend South Park from the 'Tanks' in a short minigame called the 'Penalty Round' after the stage.